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You can compare tire specs in detail on tirerack.com. There's no magin bullet, if you hit a pot hole hard enough with either tire, you are going to end up damaging - tire>rim>suspension. With a standard tire, the sidewall is going to compress faster to cushion the blow to the rest of the components vs. a run flat tire where the jolt is going to travel faster up the chain with rim and suspension taking more of the beating.
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